This question is a great opportunity to put a positive spin on something negative, but you don’t want your answer to be cliché – joking or not. Instead, try to use a real example of a weakness you have learned to overcome.
“I’ve never been very comfortable with public speaking – which as you know, can be a hindrance in the workplace. Realizing this was a problem, I asked my previous employer if I could enroll in a speech workshop. He said “yes.” I took the class, and was able to overcome my lifelong fear. Since then, I’ve given lots of presentations to audiences of over a 100 high level executives – I still don’t love it, but no one else can tell!”
“I work too hard,” or for the comedian, “Blondes.”